Born and raised north of Chicago in Mundelein, Illinois, Billy Wolfe began playing piano at the age of 5 and saxophone at the age of 10. Billy earned a bachelor of music degree from Capital University in Columbus, Ohio, where he began his professional career playing with bands such as Vaughn Wiester’s Famous Jazz Orchestra, the Dayton Jazz Orchestra, and the Brian Michael Smith-John Vermeulen Octet. In 2009, Billy decided to pursue a master of music degree from DePaul University. It was during this period that he first began exploring the creative possibilities of contemporary large ensemble music, an interest inspired by his studies with Tom Matta and experiences performing with several Chicago area new music groups.

He currently leads Billy Wolfe Octet and The Tristano School Project as well as co-leading the nine piece MW9 ensemble with Baltimore based trumpeter Leo Maxey and the New Orleans trad/funk inspired District Brass alongside David Agee. Billy is also is a member of the Bohemian Caverns Jazz Orchestra, Vaughn Wiester's Famous Jazz Orchestra, The Rick Brunetto Big Band, The Brad Linde Expanded Ensemble, Joe Duran's Projections, Will Strickler's Parallel Structures, and the avant-garde quartet/quintet, "Team Players".

Billy is also an educator in his own right, regularly maintaining a teaching studio the provides detailed instruction of saxophone, clarinet, flute and oboe. Currently, Billy is a big band and combo instructor for Capital University's Conservatory of Music and leads weekly saxophone sectionals for the Pickerington High School North..